Drug interactions
Eszopiclone + Idelalisib
Severity: Moderate
Eszopiclone and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can markedly raise eszopiclone levels. This may cause excessive sedation and psychomotor impairment.
What this interaction means in plain words
Eszopiclone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib decreases eszopiclone clearance.
What to do
Limit eszopiclone to 1 mg, maximum 2 mg. Monitor for oversedation or consider an alternative hypnotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Eszopiclone with Idelalisib?
MediHelp rates the interaction as moderate. Eszopiclone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and can markedly raise eszopiclone levels. This may cause excessive sedation and psychomotor impairment.
How serious is the interaction between Eszopiclone and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit eszopiclone to 1 mg, maximum 2 mg. Monitor for oversedation or consider an alternative hypnotic.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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