Drug interactions
Eszopiclone + Levoketoconazole
Severity: Moderate
Eszopiclone and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, and the related ketoconazole markedly increases eszopiclone exposure. Higher levels can lead to excessive sedation, impaired alertness and complex sleep behaviors.
What this interaction means in plain words
Eszopiclone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4-mediated metabolism of eszopiclone.
What to do
Cap the eszopiclone dose at 2 mg per night, starting at 1 mg. Monitor for oversedation and next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Eszopiclone with Levoketoconazole?
MediHelp rates the interaction as moderate. Eszopiclone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor, and the related ketoconazole markedly increases eszopiclone exposure. Higher levels can lead to excessive sedation, impaired alertness and complex sleep behaviors.
How serious is the interaction between Eszopiclone and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cap the eszopiclone dose at 2 mg per night, starting at 1 mg. Monitor for oversedation and next-day impairment.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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