Drug interactions
Eszopiclone + Lopinavir
Severity: Moderate
Eszopiclone and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is boosted with ritonavir, inhibits CYP3A4 and can raise eszopiclone concentrations. This may cause excess sedation and next-day psychomotor impairment.
What this interaction means in plain words
Eszopiclone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition (mainly via the ritonavir booster) reduces eszopiclone clearance.
What to do
Start eszopiclone at 1 mg and do not exceed 2 mg nightly. Monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Eszopiclone with Lopinavir?
MediHelp rates the interaction as moderate. Eszopiclone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, which is boosted with ritonavir, inhibits CYP3A4 and can raise eszopiclone concentrations. This may cause excess sedation and next-day psychomotor impairment.
How serious is the interaction between Eszopiclone and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and do not exceed 2 mg nightly. Monitor for oversedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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