Drug interactions
Eszopiclone + Rucaparib
Severity: Minor
Eszopiclone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly to moderately and may modestly raise eszopiclone exposure. The result could be increased sedation.
What this interaction means in plain words
Eszopiclone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eszopiclone belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated eszopiclone metabolism.
What to do
Start eszopiclone at the lowest dose and monitor for daytime sedation, adjusting the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eszopiclone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Eszopiclone with Rucaparib?
MediHelp rates the interaction as minor. Eszopiclone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly to moderately and may modestly raise eszopiclone exposure. The result could be increased sedation.
How serious is the interaction between Eszopiclone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at the lowest dose and monitor for daytime sedation, adjusting the dose if needed.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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