Drug interactions
Ethacrynic acid + Hydrochlorothiazide-lisinopril
Severity: Major
Ethacrynic acid and Hydrochlorothiazide-lisinopril: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces sequential nephron blockade and a strong diuretic response. This can cause marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, especially with an ACE inhibitor on board. Ethacrynic acid also carries ototoxicity risk.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive inhibition of sodium reabsorption at the loop of Henle and distal tubule, increasing urinary loss of electrolytes and water.
What to do
Monitor electrolytes, renal function, volume status and blood pressure closely, starting with low doses. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Ethacrynic acid and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a loop diuretic with a thiazide produces sequential nephron blockade and a strong diuretic response. This can cause marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, especially with an ACE inhibitor on board. Ethacrynic acid also carries ototoxicity risk.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, volume status and blood pressure closely, starting with low doses. Replace potassium and magnesium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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