Drug interactions
Ethacrynic acid + Indacaterol-glycopyrronium
Severity: Moderate
Ethacrynic acid and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause potassium loss, and beta-agonists like indacaterol can lower serum potassium further. Hypokalaemia can promote arrhythmias, particularly in patients with heart disease or QT risk.
What this interaction means in plain words
Ethacrynic acid and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive hypokalaemia from diuretic-induced renal potassium loss and beta-2 stimulated cellular potassium uptake.
What to do
Monitor serum potassium periodically, especially at initiation and in patients with cardiac disease. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Ethacrynic acid and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause potassium loss, and beta-agonists like indacaterol can lower serum potassium further. Hypokalaemia can promote arrhythmias, particularly in patients with heart disease or QT risk.
How serious is the interaction between Ethacrynic acid and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at initiation and in patients with cardiac disease. Replace potassium as needed.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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