Drug interactions
Ethacrynic acid + Labetalol
Severity: Moderate
Ethacrynic acid and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The antihypertensive effects of the two drugs are additive, which may cause excessive hypotension or orthostatic symptoms. Ethacrynic acid can also cause potassium and fluid losses.
What this interaction means in plain words
Ethacrynic acid and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from adrenergic blockade and loop diuretic-induced volume depletion.
What to do
Monitor blood pressure, volume status and electrolytes, and reduce doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Labetalol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The antihypertensive effects of the two drugs are additive, which may cause excessive hypotension or orthostatic symptoms. Ethacrynic acid can also cause potassium and fluid losses.
How serious is the interaction between Ethacrynic acid and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and electrolytes, and reduce doses if hypotension develops.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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