Drug interactions
Ethacrynic acid + Losartan
Severity: Moderate
Ethacrynic acid and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that can cause volume depletion and potassium loss. Combined with losartan, hypotension and renal function decline may occur, while losartan can partly offset the potassium loss.
What this interaction means in plain words
Ethacrynic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive hypotensive and volume-depleting effects, with opposing effects on serum potassium.
What to do
Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Consider reducing the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Losartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that can cause volume depletion and potassium loss. Combined with losartan, hypotension and renal function decline may occur, while losartan can partly offset the potassium loss.
How serious is the interaction between Ethacrynic acid and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Consider reducing the diuretic dose if the patient is volume depleted.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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