Drug interactions
Ethacrynic acid + Mefenamic acid
Severity: Moderate
Ethacrynic acid and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as mefenamic acid can blunt the diuretic and natriuretic response to loop diuretics and may impair renal function in volume-depleted patients. The combination also increases the risk of acute kidney injury, and potassium effects are variable.
What this interaction means in plain words
Ethacrynic acid and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing loop diuretic effect.
What to do
Monitor urine output, weight, blood pressure, serum creatinine and electrolytes, and increase the diuretic dose if response is reduced. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Mefenamic acid?
MediHelp rates the interaction as moderate. Ethacrynic acid and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as mefenamic acid can blunt the diuretic and natriuretic response to loop diuretics and may impair renal function in volume-depleted patients. The combination also increases the risk of acute kidney injury, and potassium effects are variable.
How serious is the interaction between Ethacrynic acid and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight, blood pressure, serum creatinine and electrolytes, and increase the diuretic dose if response is reduced. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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