Drug interactions
Ethacrynic acid + Nabumetone
Severity: Moderate
Ethacrynic acid and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and natriuretic effects of loop diuretics such as ethacrynic acid. The combination can also increase the risk of acute kidney injury, especially in volume-depleted or heart failure patients.
What this interaction means in plain words
Ethacrynic acid and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function and watch for diminished diuretic response. Use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Nabumetone?
MediHelp rates the interaction as moderate. Ethacrynic acid and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and natriuretic effects of loop diuretics such as ethacrynic acid. The combination can also increase the risk of acute kidney injury, especially in volume-depleted or heart failure patients.
How serious is the interaction between Ethacrynic acid and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function and watch for diminished diuretic response. Use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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