Drug interactions
Ethacrynic acid + Piroxicam
Severity: Moderate
Ethacrynic acid and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the diuretic effect of loop diuretics and increases the risk of renal impairment, particularly with volume depletion or heart failure.
What this interaction means in plain words
Ethacrynic acid and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Adjust diuretic dose or avoid the NSAID in heart failure or renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Piroxicam?
MediHelp rates the interaction as moderate. Ethacrynic acid and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the diuretic effect of loop diuretics and increases the risk of renal impairment, particularly with volume depletion or heart failure.
How serious is the interaction between Ethacrynic acid and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Adjust diuretic dose or avoid the NSAID in heart failure or renal disease.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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