Drug interactions
Ethacrynic acid + Tizanidine
Severity: Moderate
Ethacrynic acid and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that can cause volume depletion and hypotension. Tizanidine adds blood pressure lowering, so dizziness and orthostatic hypotension may be more likely.
What this interaction means in plain words
Ethacrynic acid and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from loop diuretic volume depletion and central alpha-2 agonism.
What to do
Monitor blood pressure, volume status and orthostatic symptoms. Reduce the dose of one agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Tizanidine?
MediHelp rates the interaction as moderate. Ethacrynic acid and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that can cause volume depletion and hypotension. Tizanidine adds blood pressure lowering, so dizziness and orthostatic hypotension may be more likely.
How serious is the interaction between Ethacrynic acid and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and orthostatic symptoms. Reduce the dose of one agent if hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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