Drug interactions
Ethinyl estradiol-drospirenone + Etravirine
Severity: Moderate
Ethinyl estradiol-drospirenone and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and can alter hormone exposure, and its effect on ethinyl estradiol is modest but it may affect contraceptive reliability. Hormonal contraceptives may be less dependable, and etravirine data are mixed.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
CYP3A4 induction by etravirine may increase metabolism of the hormones, although observed ethinyl estradiol exposure has actually been slightly increased.
What to do
Counsel on using a reliable non-hormonal or additional barrier method, and monitor for breakthrough bleeding or signs of altered hormone effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Etravirine?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and can alter hormone exposure, and its effect on ethinyl estradiol is modest but it may affect contraceptive reliability. Hormonal contraceptives may be less dependable, and etravirine data are mixed.
How serious is the interaction between Ethinyl estradiol-drospirenone and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on using a reliable non-hormonal or additional barrier method, and monitor for breakthrough bleeding or signs of altered hormone effects.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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