Drug interactions
Ethinyl estradiol-drospirenone + Flibanserin
Severity: Moderate
Ethinyl estradiol-drospirenone and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives are reported to raise flibanserin exposure, which may increase dizziness, somnolence, hypotension and syncope. Flibanserin labeling advises caution with multiple weak CYP3A4 inhibitors, and ethinyl estradiol is one of them.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4 by ethinyl estradiol decreases flibanserin metabolism and increases its plasma concentration.
What to do
Counsel on dizziness, sedation and fainting, and avoid alcohol close to dosing. Reassess flibanserin if additional CYP3A4 inhibitors are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Flibanserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Flibanserin?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives are reported to raise flibanserin exposure, which may increase dizziness, somnolence, hypotension and syncope. Flibanserin labeling advises caution with multiple weak CYP3A4 inhibitors, and ethinyl estradiol is one of them.
How serious is the interaction between Ethinyl estradiol-drospirenone and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness, sedation and fainting, and avoid alcohol close to dosing. Reassess flibanserin if additional CYP3A4 inhibitors are added.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
