Drug interactions
Ethinyl estradiol-drospirenone + Fosaprepitant
Severity: Moderate
Ethinyl estradiol-drospirenone and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor and weak inducer, which may modestly alter exposure to hormonal contraceptives. Reduced contraceptive efficacy has been described with aprepitant and may persist for some time after dosing.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant induces CYP metabolism of contraceptive steroids, potentially lowering hormone concentrations.
What to do
Advise an additional non-hormonal contraceptive method during fosaprepitant treatment and for about one month after the last dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Fosaprepitant?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor and weak inducer, which may modestly alter exposure to hormonal contraceptives. Reduced contraceptive efficacy has been described with aprepitant and may persist for some time after dosing.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during fosaprepitant treatment and for about one month after the last dose.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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