Drug interactions
Ethinyl estradiol-drospirenone + Gentamicin
Severity: Minor
Ethinyl estradiol-drospirenone and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal tubular injury with potassium and magnesium wasting, while drospirenone tends to raise potassium. If nephrotoxicity develops, reduced renal function could instead favor potassium retention with drospirenone, so the net effect is unpredictable.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Gentamicin belongs to Anti Bacterial.
Why it happens
Opposing or unpredictable potassium effects: aldosterone antagonism by drospirenone versus aminoglycoside tubular toxicity, with renal impairment possibly increasing retention.
What to do
Monitor serum potassium and renal function during gentamicin therapy in patients on this contraceptive. Stop drospirenone-containing products if significant renal impairment or hyperkalemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Gentamicin?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gentamicin can cause renal tubular injury with potassium and magnesium wasting, while drospirenone tends to raise potassium. If nephrotoxicity develops, reduced renal function could instead favor potassium retention with drospirenone, so the net effect is unpredictable.
How serious is the interaction between Ethinyl estradiol-drospirenone and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during gentamicin therapy in patients on this contraceptive. Stop drospirenone-containing products if significant renal impairment or hyperkalemia occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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