Drug interactions
Ethinyl estradiol-drospirenone + Iloperidone
Severity: Minor
Ethinyl estradiol-drospirenone and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is only a weak CYP3A inhibitor in practice, so any rise in ethinyl estradiol exposure is expected to be small. Clinical consequences are unlikely.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 may slightly reduce ethinyl estradiol metabolism.
What to do
No dose change is needed; watch for increased estrogenic adverse effects such as nausea or breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Iloperidone?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is only a weak CYP3A inhibitor in practice, so any rise in ethinyl estradiol exposure is expected to be small. Clinical consequences are unlikely.
How serious is the interaction between Ethinyl estradiol-drospirenone and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; watch for increased estrogenic adverse effects such as nausea or breast tenderness.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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