Drug interactions
Ethinyl estradiol-drospirenone + Lonafarnib
Severity: Moderate
Ethinyl estradiol-drospirenone and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A inhibitor and lonafarnib is a sensitive CYP3A substrate, so lonafarnib levels may rise modestly. This could increase lonafarnib toxicity, including gastrointestinal effects and possible QT concerns.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak CYP3A inhibition by ethinyl estradiol reduces lonafarnib metabolism.
What to do
Monitor for lonafarnib adverse effects and palpitations or syncope. Follow labeling for lonafarnib dose adjustment with weak CYP3A inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Lonafarnib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Lonafarnib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP3A inhibitor and lonafarnib is a sensitive CYP3A substrate, so lonafarnib levels may rise modestly. This could increase lonafarnib toxicity, including gastrointestinal effects and possible QT concerns.
How serious is the interaction between Ethinyl estradiol-drospirenone and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects and palpitations or syncope. Follow labeling for lonafarnib dose adjustment with weak CYP3A inhibitors.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
