Drug interactions
Ethinyl estradiol-drospirenone + Losartan
Severity: Moderate
Ethinyl estradiol-drospirenone and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity, and losartan reduces aldosterone effects through angiotensin receptor blockade. Combined use can cause hyperkalemia, particularly with renal impairment or diabetes.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Additive potassium retention via drospirenone aldosterone antagonism and angiotensin II receptor blockade.
What to do
Measure serum potassium during the first cycle and periodically thereafter. Choose a contraceptive without drospirenone if baseline potassium is high or renal function is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Losartan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity, and losartan reduces aldosterone effects through angiotensin receptor blockade. Combined use can cause hyperkalemia, particularly with renal impairment or diabetes.
How serious is the interaction between Ethinyl estradiol-drospirenone and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle and periodically thereafter. Choose a contraceptive without drospirenone if baseline potassium is high or renal function is poor.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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