Drug interactions
Ethinyl estradiol-drospirenone + Metoprolol
Severity: Minor
Ethinyl estradiol-drospirenone and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can slightly raise serum potassium, and drospirenone can also raise it. The combined effect is generally small but may matter with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Metoprolol belongs to Cardiovascular.
Why it happens
Mild additive effect: beta-blockade reduces cellular potassium uptake while drospirenone reduces renal potassium excretion.
What to do
No routine change; check potassium if renal impairment or other potassium-raising agents are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Metoprolol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can slightly raise serum potassium, and drospirenone can also raise it. The combined effect is generally small but may matter with renal impairment or other potassium-raising drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; check potassium if renal impairment or other potassium-raising agents are present.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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