Drug interactions
Ethinyl estradiol-drospirenone + Midazolam
Severity: Minor
Ethinyl estradiol-drospirenone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol may modestly reduce the oxidative clearance of midazolam, leading to somewhat higher exposure and stronger or longer sedation. The effect is generally small and manageable.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated midazolam metabolism by ethinyl estradiol.
What to do
Titrate midazolam to clinical effect and monitor sedation and respiratory status, particularly with repeated or higher doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Midazolam?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol may modestly reduce the oxidative clearance of midazolam, leading to somewhat higher exposure and stronger or longer sedation. The effect is generally small and manageable.
How serious is the interaction between Ethinyl estradiol-drospirenone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect and monitor sedation and respiratory status, particularly with repeated or higher doses.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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