Drug interactions
Ethinyl estradiol-drospirenone + Nitrofurantoin
Severity: Minor
Ethinyl estradiol-drospirenone and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrofurantoin has been theorized to reduce ethinyl estradiol levels through effects on gut flora. No convincing evidence shows reduced contraceptive efficacy.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Theoretical disruption of enterohepatic recycling of ethinyl estradiol via altered gut flora; not established.
What to do
No change is needed; remind the patient to take pills consistently and to use backup contraception if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Nitrofurantoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Nitrofurantoin?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrofurantoin has been theorized to reduce ethinyl estradiol levels through effects on gut flora. No convincing evidence shows reduced contraceptive efficacy.
How serious is the interaction between Ethinyl estradiol-drospirenone and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed; remind the patient to take pills consistently and to use backup contraception if vomiting or diarrhea occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
