Drug interactions
Ethinyl estradiol-drospirenone + Ospemifene
Severity: Moderate
Ethinyl estradiol-drospirenone and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is an estrogen agonist/antagonist and has additive or opposing hormonal effects with estrogen-containing products. Its labeling advises against use with estrogens or estrogen agonists/antagonists because safety of the combination has not been established.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Ospemifene belongs to Endocrine.
Why it happens
Overlapping estrogen receptor activity with ethinyl estradiol; pharmacodynamic rather than CYP3A4-mediated.
What to do
Avoid concurrent use; ospemifene is intended for postmenopausal women who would not normally need a contraceptive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Ospemifene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ospemifene?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is an estrogen agonist/antagonist and has additive or opposing hormonal effects with estrogen-containing products. Its labeling advises against use with estrogens or estrogen agonists/antagonists because safety of the combination has not been established.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; ospemifene is intended for postmenopausal women who would not normally need a contraceptive.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
