Drug interactions
Ethinyl estradiol-drospirenone + Succinylcholine
Severity: Moderate
Ethinyl estradiol-drospirenone and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can cause an acute rise in serum potassium, which may be dangerous in patients with already elevated potassium. Drospirenone could add to potassium retention, though the contribution is small in healthy patients.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine causes potassium efflux from muscle, adding to drospirenone-related renal potassium retention.
What to do
Check baseline serum potassium before elective surgery in patients with renal impairment or other hyperkalemia risks. Choose a non-depolarizing neuromuscular blocker if potassium is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Succinylcholine?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can cause an acute rise in serum potassium, which may be dangerous in patients with already elevated potassium. Drospirenone could add to potassium retention, though the contribution is small in healthy patients.
How serious is the interaction between Ethinyl estradiol-drospirenone and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline serum potassium before elective surgery in patients with renal impairment or other hyperkalemia risks. Choose a non-depolarizing neuromuscular blocker if potassium is elevated.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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