Drug interactions
Ethinyl estradiol-drospirenone + Ursodiol
Severity: Minor
Ethinyl estradiol-drospirenone and Ursodiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens increase biliary cholesterol saturation and may promote gallstone formation, which is opposite to the gallstone-dissolving purpose of ursodiol. The clinical effect on ursodiol therapy is mainly theoretical and is of greatest relevance when ursodiol is used for gallstone dissolution.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ursodiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Ursodiol belongs to Gastrointestinal Tract.
Why it happens
Estrogens raise biliary cholesterol secretion and saturation, pharmacodynamically opposing the cholesterol-lowering effect of ursodiol in bile.
What to do
If ursodiol is used for gallstone dissolution, consider a non-estrogen contraceptive and monitor gallstone response by imaging. No action is generally needed for primary biliary cholangitis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Ursodiol
- Aluminum hydroxide + Ursodiol Moderate
- Cholestyramine + Ursodiol Moderate
- Colesevelam + Ursodiol Moderate
- Colestipol + Ursodiol Moderate
- Desogestrel-ethinyl estradiol + Ursodiol Moderate
- Ethinyl estradiol-levonorgestrel + Ursodiol Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ursodiol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Ursodiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens increase biliary cholesterol saturation and may promote gallstone formation, which is opposite to the gallstone-dissolving purpose of ursodiol. The clinical effect on ursodiol therapy is mainly theoretical and is of greatest relevance when ursodiol is used for gallstone dissolution.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ursodiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If ursodiol is used for gallstone dissolution, consider a non-estrogen contraceptive and monitor gallstone response by imaging. No action is generally needed for primary biliary cholangitis.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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