Drug interactions
Ethinyl estradiol-drospirenone + Voriconazole
Severity: Moderate
Ethinyl estradiol-drospirenone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and has been shown to raise ethinyl estradiol and progestin exposure. This may increase estrogen-related adverse effects such as nausea, breast tenderness and possibly thrombotic risk.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ethinyl estradiol and drospirenone by voriconazole.
What to do
Monitor for estrogenic adverse effects, and consider a lower-dose or alternative contraceptive if they occur. Drospirenone-treated patients should have potassium monitored.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Voriconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and has been shown to raise ethinyl estradiol and progestin exposure. This may increase estrogen-related adverse effects such as nausea, breast tenderness and possibly thrombotic risk.
How serious is the interaction between Ethinyl estradiol-drospirenone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects, and consider a lower-dose or alternative contraceptive if they occur. Drospirenone-treated patients should have potassium monitored.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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