Drug interactions
Etodolac + Hydrochlorothiazide
Severity: Moderate
Etodolac and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury.
What this interaction means in plain words
Etodolac and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion, opposing thiazide natriuresis.
What to do
Monitor blood pressure, fluid status and renal function, and ensure adequate hydration. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Etodolac with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Etodolac and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury.
How serious is the interaction between Etodolac and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, and ensure adequate hydration. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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