Drug interactions
Etodolac + Sotalol
Severity: Moderate
Etodolac and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use may reduce the antihypertensive effect of sotalol. Reduced blood pressure control may appear after prolonged combined use.
What this interaction means in plain words
Etodolac and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention oppose beta blockade.
What to do
Monitor blood pressure and adjust therapy if needed; limit NSAID duration. Check renal function and electrolytes, since sotalol accumulates with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Etodolac with Sotalol?
MediHelp rates the interaction as moderate. Etodolac and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use may reduce the antihypertensive effect of sotalol. Reduced blood pressure control may appear after prolonged combined use.
How serious is the interaction between Etodolac and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust therapy if needed; limit NSAID duration. Check renal function and electrolytes, since sotalol accumulates with renal impairment.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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