Drug interactions
Etomidate + Fluphenazine
Severity: Moderate
Etomidate and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a sedative-hypnotic anesthetic, and fluphenazine adds CNS depressant and hypotensive effects, so the combination may deepen sedation and lower blood pressure during anesthesia induction. Anesthetic requirements may be altered in patients on phenothiazines.
What this interaction means in plain words
Etomidate and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression (GABA-A potentiation by etomidate plus phenothiazine sedative and alpha-blocking effects).
What to do
Titrate etomidate carefully and monitor blood pressure, airway and sedation depth during and after induction. Inform the anesthesia team of ongoing antipsychotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Fluphenazine?
MediHelp rates the interaction as moderate. Etomidate and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is a sedative-hypnotic anesthetic, and fluphenazine adds CNS depressant and hypotensive effects, so the combination may deepen sedation and lower blood pressure during anesthesia induction. Anesthetic requirements may be altered in patients on phenothiazines.
How serious is the interaction between Etomidate and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate carefully and monitor blood pressure, airway and sedation depth during and after induction. Inform the anesthesia team of ongoing antipsychotic therapy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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