Drug interactions
Etomidate + Hydroxyzine
Severity: Moderate
Etomidate and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent and hydroxyzine is sedating, so they may add to sedation and recovery time. In monitored anesthetic settings this is usually manageable.
What this interaction means in plain words
Etomidate and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation by etomidate and central H1 antagonism.
What to do
Inform the anesthesia team of recent hydroxyzine use and titrate etomidate to effect with continuous monitoring of airway and hemodynamics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Hydroxyzine?
MediHelp rates the interaction as moderate. Etomidate and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent and hydroxyzine is sedating, so they may add to sedation and recovery time. In monitored anesthetic settings this is usually manageable.
How serious is the interaction between Etomidate and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent hydroxyzine use and titrate etomidate to effect with continuous monitoring of airway and hemodynamics.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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