Drug interactions
Etomidate + Midazolam
Severity: Moderate
Etomidate and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam and etomidate both depress consciousness and are often combined in anesthesia induction. Together they have additive sedative and hypnotic effects, and may increase hypotension or respiratory depression.
What this interaction means in plain words
Etomidate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor mediated CNS depression.
What to do
Titrate doses carefully, usually reducing the etomidate dose when midazolam premedication is given, and monitor blood pressure, oxygen saturation and ventilation continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Midazolam?
MediHelp rates the interaction as moderate. Etomidate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam and etomidate both depress consciousness and are often combined in anesthesia induction. Together they have additive sedative and hypnotic effects, and may increase hypotension or respiratory depression.
How serious is the interaction between Etomidate and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses carefully, usually reducing the etomidate dose when midazolam premedication is given, and monitor blood pressure, oxygen saturation and ventilation continuously.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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