Drug interactions
Etomidate + Promethazine
Severity: Moderate
Etomidate and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and prior or concurrent promethazine can enhance sedation and may deepen hypotension or prolong recovery. The combination is manageable in monitored anesthetic settings.
What this interaction means in plain words
Etomidate and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation by etomidate and H1 antagonism by promethazine.
What to do
Titrate the etomidate dose to effect and monitor airway, blood pressure and recovery time; the anesthesia team should account for recent promethazine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Promethazine?
MediHelp rates the interaction as moderate. Etomidate and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and prior or concurrent promethazine can enhance sedation and may deepen hypotension or prolong recovery. The combination is manageable in monitored anesthetic settings.
How serious is the interaction between Etomidate and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the etomidate dose to effect and monitor airway, blood pressure and recovery time; the anesthesia team should account for recent promethazine use.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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