Drug interactions
Etonogestrel + Etravirine
Severity: Moderate
Etonogestrel and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower progestin concentrations, which could reduce contraceptive reliability. Clinical data on implants are limited.
What this interaction means in plain words
Etonogestrel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by etravirine increases etonogestrel clearance.
What to do
Counsel on using condoms in addition to the implant, or consider an alternative such as DMPA or a copper IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etonogestrel with Etravirine?
MediHelp rates the interaction as moderate. Etonogestrel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower progestin concentrations, which could reduce contraceptive reliability. Clinical data on implants are limited.
How serious is the interaction between Etonogestrel and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on using condoms in addition to the implant, or consider an alternative such as DMPA or a copper IUD.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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