Drug interactions
Etonogestrel + Itraconazole
Severity: Minor
Etonogestrel and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase etonogestrel exposure from implants or vaginal rings. The practical consequence is usually increased progestogenic adverse effects rather than loss of contraceptive efficacy.
What this interaction means in plain words
Etonogestrel and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated metabolism of etonogestrel.
What to do
No dose adjustment is generally required; counsel the patient about possible bleeding changes or progestogenic effects and reassess if they are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Itraconazole?
MediHelp rates the interaction as minor. Etonogestrel and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may increase etonogestrel exposure from implants or vaginal rings. The practical consequence is usually increased progestogenic adverse effects rather than loss of contraceptive efficacy.
How serious is the interaction between Etonogestrel and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; counsel the patient about possible bleeding changes or progestogenic effects and reassess if they are troublesome.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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