Drug interactions
Etonogestrel + Letermovir
Severity: Minor
Etonogestrel and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise etonogestrel concentrations. It also induces CYP2C9 and CYP2C19, but contraceptive efficacy is not expected to fall.
What this interaction means in plain words
Etonogestrel and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Moderate CYP3A inhibition by letermovir reduces etonogestrel metabolism.
What to do
No routine adjustment; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Etonogestrel with Letermovir?
MediHelp rates the interaction as minor. Etonogestrel and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor and may raise etonogestrel concentrations. It also induces CYP2C9 and CYP2C19, but contraceptive efficacy is not expected to fall.
How serious is the interaction between Etonogestrel and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for progestogenic adverse effects.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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