Drug interactions
Etonogestrel + Voriconazole
Severity: Minor
Etonogestrel and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase etonogestrel exposure, which would raise progestogenic adverse effects such as irregular bleeding, headache, and mood changes. Contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Etonogestrel and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, which metabolizes etonogestrel.
What to do
No dose adjustment is generally needed. Counsel the patient about bleeding pattern changes and other progestogenic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Voriconazole?
MediHelp rates the interaction as minor. Etonogestrel and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole can increase etonogestrel exposure, which would raise progestogenic adverse effects such as irregular bleeding, headache, and mood changes. Contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Etonogestrel and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Counsel the patient about bleeding pattern changes and other progestogenic effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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