Drug interactions
Etrasimod + Teriflunomide
Severity: Moderate
Etrasimod and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Teriflunomide is a weak CYP2C8 inhibitor, and in CYP2C9 poor metabolizers this could raise etrasimod exposure. Teriflunomide also adds immunosuppressive effects.
What this interaction means in plain words
Etrasimod and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP2C8 inhibition by teriflunomide may reduce etrasimod clearance, and both drugs have additive immune effects.
What to do
Avoid the combination in known CYP2C9 poor metabolizers. In other patients, monitor for etrasimod adverse effects such as bradycardia and for infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Teriflunomide?
MediHelp rates the interaction as moderate. Etrasimod and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Teriflunomide is a weak CYP2C8 inhibitor, and in CYP2C9 poor metabolizers this could raise etrasimod exposure. Teriflunomide also adds immunosuppressive effects.
How serious is the interaction between Etrasimod and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in known CYP2C9 poor metabolizers. In other patients, monitor for etrasimod adverse effects such as bradycardia and for infections.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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