Drug interactions
Etravirine + Fluvoxamine
Severity: Moderate
Etravirine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is metabolized by CYP2C19, CYP3A4 and CYP2C9, and fluvoxamine inhibits CYP2C19, which may increase etravirine concentrations. Increased exposure may cause rash and other adverse effects, though it is usually tolerated.
What this interaction means in plain words
Etravirine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Fluvoxamine belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by fluvoxamine reduces etravirine metabolism.
What to do
Monitor for etravirine adverse effects such as rash and consider an alternative antidepressant if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Fluvoxamine?
MediHelp rates the interaction as moderate. Etravirine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is metabolized by CYP2C19, CYP3A4 and CYP2C9, and fluvoxamine inhibits CYP2C19, which may increase etravirine concentrations. Increased exposure may cause rash and other adverse effects, though it is usually tolerated.
How serious is the interaction between Etravirine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for etravirine adverse effects such as rash and consider an alternative antidepressant if problems arise.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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