Drug interactions
Etravirine + Itraconazole
Severity: Moderate
Etravirine and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower itraconazole concentrations, while itraconazole may increase etravirine exposure. The net effect is that antifungal efficacy may be reduced.
What this interaction means in plain words
Etravirine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Itraconazole belongs to Anti Fungals.
Why it happens
Etravirine induces CYP3A4 and itraconazole inhibits CYP3A4, so effects on both drugs' concentrations are bidirectional.
What to do
Monitor for reduced antifungal response and consider measuring itraconazole concentrations, with dose adjustment as needed. Take care if other interacting drugs such as boosted protease inhibitors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Itraconazole?
MediHelp rates the interaction as moderate. Etravirine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower itraconazole concentrations, while itraconazole may increase etravirine exposure. The net effect is that antifungal efficacy may be reduced.
How serious is the interaction between Etravirine and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antifungal response and consider measuring itraconazole concentrations, with dose adjustment as needed. Take care if other interacting drugs such as boosted protease inhibitors are present.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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