Drug interactions
Etravirine + Losartan
Severity: Moderate
Etravirine and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and induces CYP3A4, which may change conversion of losartan to its active metabolite. The net effect is unpredictable and may alter blood pressure control.
What this interaction means in plain words
Etravirine and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Losartan belongs to Cardiovascular.
Why it happens
Etravirine inhibits CYP2C9 and induces CYP3A4, both involved in losartan metabolism.
What to do
Monitor blood pressure when etravirine is started or stopped and titrate losartan to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Losartan?
MediHelp rates the interaction as moderate. Etravirine and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C9 and induces CYP3A4, which may change conversion of losartan to its active metabolite. The net effect is unpredictable and may alter blood pressure control.
How serious is the interaction between Etravirine and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when etravirine is started or stopped and titrate losartan to response.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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