Drug interactions
Etravirine + Mefloquine
Severity: Moderate
Etravirine and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest CYP3A4 inducer and may lower mefloquine concentrations. This could reduce prophylactic or therapeutic antimalarial efficacy.
What this interaction means in plain words
Etravirine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Mefloquine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 increases mefloquine clearance.
What to do
Monitor for malaria prophylaxis or treatment failure. Consider an alternative antimalarial if adequate exposure is in doubt.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Mefloquine?
MediHelp rates the interaction as moderate. Etravirine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a modest CYP3A4 inducer and may lower mefloquine concentrations. This could reduce prophylactic or therapeutic antimalarial efficacy.
How serious is the interaction between Etravirine and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for malaria prophylaxis or treatment failure. Consider an alternative antimalarial if adequate exposure is in doubt.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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