Drug interactions
Etravirine + Norethisterone
Severity: Minor
Etravirine and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may reduce norethisterone exposure, although it has had little effect on ethinylestradiol-norethindrone combinations in studies. Contraceptive efficacy is probably maintained but data are limited.
What this interaction means in plain words
Etravirine and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Norethisterone belongs to Endocrine.
Why it happens
Weak-to-moderate CYP3A4 induction by etravirine may increase norethisterone clearance.
What to do
No routine dose change is needed; counsel on possible breakthrough bleeding and consider a backup method if there is concern about efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Norethisterone?
MediHelp rates the interaction as minor. Etravirine and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a CYP3A4 inducer and may reduce norethisterone exposure, although it has had little effect on ethinylestradiol-norethindrone combinations in studies. Contraceptive efficacy is probably maintained but data are limited.
How serious is the interaction between Etravirine and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel on possible breakthrough bleeding and consider a backup method if there is concern about efficacy.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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