Drug interactions
Etravirine + Omeprazole
Severity: Moderate
Etravirine and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C19, the main enzyme clearing omeprazole, so omeprazole exposure can rise. This is usually well tolerated, though higher omeprazole exposure may matter with long-term use or high doses.
What this interaction means in plain words
Etravirine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Etravirine inhibits CYP2C19, reducing omeprazole metabolism.
What to do
Consider omeprazole dose reduction if high doses are used for prolonged periods. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Omeprazole?
MediHelp rates the interaction as moderate. Etravirine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C19, the main enzyme clearing omeprazole, so omeprazole exposure can rise. This is usually well tolerated, though higher omeprazole exposure may matter with long-term use or high doses.
How serious is the interaction between Etravirine and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider omeprazole dose reduction if high doses are used for prolonged periods. Monitor for adverse effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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