Drug interactions
Etravirine + Osimertinib
Severity: Moderate
Etravirine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower osimertinib exposure. This could reduce antitumor efficacy, although the effect is expected to be smaller than with strong inducers.
What this interaction means in plain words
Etravirine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Osimertinib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4, increasing osimertinib metabolic clearance.
What to do
Consider an alternative antiretroviral without enzyme-inducing activity. If combined, monitor tumor response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osimertinib
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Osimertinib?
MediHelp rates the interaction as moderate. Etravirine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower osimertinib exposure. This could reduce antitumor efficacy, although the effect is expected to be smaller than with strong inducers.
How serious is the interaction between Etravirine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral without enzyme-inducing activity. If combined, monitor tumor response closely.
What other medicines interact with Osimertinib?
MediHelp also lists interactions of Osimertinib with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Osimertinib page.
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