Drug interactions
Etravirine + Piroxicam
Severity: Minor
Etravirine and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 to a modest degree and may modestly increase piroxicam concentrations. The effect is likely small but could add to NSAID-related gastrointestinal and renal risk.
What this interaction means in plain words
Etravirine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Piroxicam belongs to Musculoskeletal.
Why it happens
Etravirine inhibition of CYP2C9 reduces piroxicam metabolism.
What to do
No routine adjustment is required; use the lowest effective piroxicam dose and monitor for gastrointestinal bleeding signs and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Piroxicam?
MediHelp rates the interaction as minor. Etravirine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine inhibits CYP2C9 to a modest degree and may modestly increase piroxicam concentrations. The effect is likely small but could add to NSAID-related gastrointestinal and renal risk.
How serious is the interaction between Etravirine and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; use the lowest effective piroxicam dose and monitor for gastrointestinal bleeding signs and renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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