Drug interactions
Etravirine + Ribociclib
Severity: Moderate
Etravirine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer, which may lower ribociclib concentrations and reduce its efficacy. Ribociclib may raise etravirine levels via CYP3A4 inhibition, although the net effect on each drug is uncertain.
What this interaction means in plain words
Etravirine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ribociclib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4 while ribociclib inhibits it, so the net effect on exposure is uncertain.
What to do
Where possible choose an antiretroviral without CYP3A induction. If combined, monitor for ribociclib loss of efficacy and for etravirine adverse effects such as rash.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ribociclib?
MediHelp rates the interaction as moderate. Etravirine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer, which may lower ribociclib concentrations and reduce its efficacy. Ribociclib may raise etravirine levels via CYP3A4 inhibition, although the net effect on each drug is uncertain.
How serious is the interaction between Etravirine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antiretroviral without CYP3A induction. If combined, monitor for ribociclib loss of efficacy and for etravirine adverse effects such as rash.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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