Drug interactions
Etravirine + Rilpivirine
Severity: Major
Etravirine and Rilpivirine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NNRTIs offers no added efficacy and adds toxicity and cross-resistance concerns. Etravirine induction may also lower rilpivirine concentrations.
What this interaction means in plain words
Etravirine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etravirine belongs to Anti Virals; Rilpivirine belongs to Anti Virals.
Why it happens
Etravirine CYP3A4 induction may reduce rilpivirine exposure, plus duplicate NNRTI class with overlapping resistance.
What to do
Do not coadminister; use only one NNRTI in the regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Rilpivirine?
MediHelp rates the interaction as major. Etravirine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NNRTIs offers no added efficacy and adds toxicity and cross-resistance concerns. Etravirine induction may also lower rilpivirine concentrations.
How serious is the interaction between Etravirine and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use only one NNRTI in the regimen.
What other medicines interact with Rilpivirine?
MediHelp also lists interactions of Rilpivirine with, for example, Carbamazepine, Dexamethasone, Dexlansoprazole. The full list is on the Rilpivirine page.
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