Drug interactions
Etravirine + Simvastatin
Severity: Moderate
Etravirine and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower simvastatin concentrations. This can reduce the lipid-lowering effect, which matters in patients with HIV who have elevated cardiovascular risk.
What this interaction means in plain words
Etravirine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Why it happens
Etravirine induces CYP3A4, increasing simvastatin metabolism.
What to do
Monitor the lipid profile and titrate simvastatin accordingly, or choose an alternative statin such as rosuvastatin or pravastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Simvastatin?
MediHelp rates the interaction as moderate. Etravirine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower simvastatin concentrations. This can reduce the lipid-lowering effect, which matters in patients with HIV who have elevated cardiovascular risk.
How serious is the interaction between Etravirine and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and titrate simvastatin accordingly, or choose an alternative statin such as rosuvastatin or pravastatin.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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