Drug interactions
Etravirine + Sirolimus
Severity: Major
Etravirine and Sirolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine can lower sirolimus concentrations, risking subtherapeutic immunosuppression and graft rejection in transplant patients. The effect is variable.
What this interaction means in plain words
Etravirine and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etravirine belongs to Anti Virals; Sirolimus belongs to Miscellaneous.
Why it happens
Etravirine induces CYP3A4, increasing sirolimus metabolism.
What to do
Monitor sirolimus trough concentrations after starting or stopping etravirine and adjust the dose accordingly. Consider an alternative antiretroviral if levels cannot be maintained.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Sirolimus?
MediHelp rates the interaction as major. Etravirine and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine can lower sirolimus concentrations, risking subtherapeutic immunosuppression and graft rejection in transplant patients. The effect is variable.
How serious is the interaction between Etravirine and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations after starting or stopping etravirine and adjust the dose accordingly. Consider an alternative antiretroviral if levels cannot be maintained.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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