Drug interactions
Etravirine + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Major
Etravirine and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is an inducer of CYP3A4 and other pathways and is expected to reduce velpatasvir and voxilaprevir exposure. Lower concentrations may reduce efficacy and risk virologic failure.
What this interaction means in plain words
Etravirine and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etravirine belongs to Anti Virals; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and P-glycoprotein, increasing clearance and reducing absorption of velpatasvir and voxilaprevir.
What to do
Avoid the combination; switch to an alternative antiretroviral such as an integrase inhibitor-based regimen or select another hepatitis C regimen with HIV pharmacist input.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as major. Etravirine and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine is an inducer of CYP3A4 and other pathways and is expected to reduce velpatasvir and voxilaprevir exposure. Lower concentrations may reduce efficacy and risk virologic failure.
How serious is the interaction between Etravirine and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; switch to an alternative antiretroviral such as an integrase inhibitor-based regimen or select another hepatitis C regimen with HIV pharmacist input.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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